Rola mitochondriów w odporności przeciwwirusowej
1. Wstęp. 2. Udział mitochondriów w produkcji IFN typu I oraz cytokin prozapalnych. 3. Wirusowe mechanizmy hamowania zależnej od mitochondriów produkcji IFN typu I oraz cytokin prozapalnych. 4. Apoptoza – proces „pseudoprzeciwwirusowy”. 5. Podsumowanie
Abstract: Mitochondria, which are known as “powerhouse” of the cell, have numerous important functions in cellular metabolism and are involved in cellular innate antiviral immunity in vertebrates. They participate in an intrinsic pathway of apoptosis and production of proinflammatory cytokines and type I interferons (IFNs; α/β). These functions are essential for limiting the spread of viral infection before the stimulation of adaptive immunity. However, viruses have evolved the ability to escape from the mechanisms of immune response including those related to mitochondrial functions. Viruses can exploit these organelles in their replication cycle and/or morphogenesis process, therefore the answer to the question about the exact role of mitochondria during viral infection is not unequivocal.
1. Introduction. 2. Contribution of mitochondria in type I IFN and pro-inflammatory cytokines production. 3. Viral inhibition mechanisms of the mitochondrial-dependent production of type I IFN and pro-inflammatory cytokines. 4. Apoptosis – “pseudoantiviral” process. 5. Summary
